产品货号：
Z10035
中文名称：
ABCA1抗体
英文名称：
Anti-ABCA1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ABCA1 Antibody |
| 指标别名 | ABC-1;ABC1;CERP;FLJ14958;HDLDT1;MGC164864;MGC165011;TGD |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | ABCA1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA1 (2231-2261aa KDLSLHKNQTVVDVAVLTSFLQDEKVKESYV),identical to the related mouse sequence. |
| 实际分子量 | 254KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ABCA1 (ATP-binding cassette,sub-family A (ABC1),member 1),also known as ABC1,the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intracellular membranes contain 2,261 amino acids.Dot blot analysis of 50 tissues revealed ubiquitous expression of ABCA1 mRNA,with highest expression in placenta,liver,lung,adrenal glands,and all fetal tissues examined,and lowest expression in kidney,pancreas,pituitary,mammary gland,and bone marrow.This protein is a member of the ABCA subfamily.Members of the ABCA subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.With cholesterol as its substrate,this protein functions as a cholesterolefflux pump in the cellular lipid removal pathway.Using human ABCA1 expressed in the membrane fraction of sf9 insect cells,Szakacs et al.found specific,Mg(2+)-dependent ATP binding and low basal ATPase activity.Addition of potential lipid substrates or lipid acceptors did not modify the ATPase activity or nucleotide occlusion by ABCA1.Szakacs et al.speculated that ABCA1 may be a regulatory protein or may require other protein partners for full activation. |
| Uniprot ID | O95477 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | ATP-binding cassette,sub-family A (ABC1),member 1 |
| 蛋白名全称 | ATP-binding cassette sub-family A member 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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